Antibiotic-resistant bacteria continue to be a global concern with devastating repercussions, such as increased health care costs, potential spread of infections across continents, and prolonged illness.However, researchers at Harvard-affiliated Brigham and Women’s Hospital (BWH) could change the playing field of man versus bacteria. Charles Serhan, the Simon Gelman Professor of Anaesthesia at Harvard Medical School (HMS), and director of the BWH Experimental Therapeutics and Reperfusion Injury Center, has identified pathways of naturally occurring molecules in our bodies that can enhance antibiotic performance.The study was published electronically today in Nature.Mice infected with Escherichia coli (E. coli) or Staphylococcus aureus (S. aureus) bacteria were given molecules called specialized pro-resolving mediators (SPMs) along with antibiotics. SPMs are naturally found in our bodies, and are responsible for mediating anti-inflammatory responses and resolving inflammation. An anti-inflammatory response is the body’s attempt to protect itself from infectious agents and initiate the healing process.The researchers found that specific types of SPM molecules, called resolvins and protectins, were key in the anti-inflammatory response to limit tissue damage by stimulating the body’s white blood cells to contain, kill, and clear the bacteria.Administered with antibiotics, resolvins and protectins heightened immune response by commanding white blood cells to attack and engulf the bacteria, thereby quickly reducing the amount of bacteria in the blood and tissues.RvD5 — a type of resolvin — in particular was also helpful in regulating fever caused by E. coli, as well as counterregulating genes responsible for mounting excess inflammation associated with infections; hence, limiting the collateral damage to the body while fighting infection.Serhan and colleagues are the first to demonstrate RvD5, as well as its actions against bacterial invasion. The BWH team, collaborating with Fredrik Bäckhed of the Sahlgrenska Center for Cardiovascular and Metabolic Research in Sweden, found that germ-free animals produce high levels of resolvins.When lead study author HMS Assistant Professor of Anesthesia Nan Chiang of the BWH Experimental Therapeutics and Reperfusion Injury Center, added these natural mediators together with antibiotics, less antibiotic was needed. This demonstrated for the first time that stimulating resolution programs can limit negative consequences of infection.“How the body responds to inflammation has been the subject of Dr. Serhan’s work for more than 20 years, and his new study is important for understanding that sequence of events,” said Richard Okita, National Institute of General Medical Sciences, National Institutes of Health, which funded the research. “One of the particularly exciting findings is that SPMs can enhance the effectiveness of antibiotics, potentially lowering the amount needed to treat infections and reducing the risk of bacteria developing resistance.”According to the researchers, another advantage of SPMs is that, unlike anti-inflammatory drugs (e.g., aspirin, steroids, ibuprofen), SPMs do not cripple the body’s normal immune response.“Anti-inflammatory agents are widely known to be immunosuppressive,” said Serhan. “Now we have naturally occurring molecular pathways in our bodies that work like these agents and stimulate bacterial containment and resolution of infections, but do not come with the side effect of being immunosuppressive.”This research was 100 percent supported by the following grants from the National Institutes of Health and National Institute of General Medical Sciences
However, in acknowledging Ferdinand is presently putting plans in place for a testimonial game, which currently has no date, or opponent but will take place at the start of next season, it seems the Londoner is ready to commit himself to United for another year. “I have spoken to Rio,” said Ferguson. “I would imagine the best thing for him would be to stay but at this moment in time he is more concerned about getting an opponent for his testimonial game. But we want him to stay and I am sure his representatives will be talking about that with David (Gill).” Of particular significance could be whether Ferdinand resumes his international career. After being selected for the recent World Cup qualifiers with San Marino and Montenegro, Ferdinand withdrew in controversial circumstances, citing an “intricate and pre-planned” training programme. That move, and his subsequent decision to fly to Doha to commentate on the first of those World Cup qualifiers for Al Jazeera, led to Ferdinand being abused by England fans during the San Marino game, which is still the subject of a FIFA investigation. Yet England boss Roy Hodgson must realise his central defensive options are no more extensive than they were prior to Ferdinand being called up in the first place. Phil Jagielka missed Everton’s defeat at Sunderland on Saturday with an ankle injury, Joleon Lescott was pressed into service as an emergency striker as Manchester City slid to defeat at Tottenham, when Steven Caulker remained on the bench throughout. At Ferdinand’s own club, neither Chris Smalling nor Phil Jones – who has impressed in a variety of positions recently – is challenging to displace their vastly experienced team-mate on a regular basis. So, there would appear to be a ring of truth about speculation that Hodgson intends to speak with Ferdinand to establish whether his training regime would allow a call-up for the post-season friendlies against Republic of Ireland on May 29 and Brazil in Rio de Janeiro on June 2. The clearest indication yet that Rio Ferdinand will be staying at Manchester United next season has come from a confirmation that the defender has been given a testimonial by the Old Trafford outfit. Press Association Ferdinand joined United for £29.1million from Leeds in 2002, meaning he completed a decade of service last summer. With his contract due to expire this year, there had been plenty of speculation about whether Ferdinand would stay, or if he might be tempted to accept one of the lucrative offers he has received to play in the Far East or Major League Soccer. So far, there has been no confirmation either way.
MORE: Full betting preview for 49ers vs. PackersIn every season since the NFL expanded to 32 teams and realigned into eight divisions in 2002, at least one team has won its division the season after missing the playoffs. After both missed the playoffs in 2018, the 49ers and Packers currently stand as the top two seeds in the NFC, lead their respective divisions through 10 games and are positioned to continue that trend.With a win over Green Bay, San Francisco, which finished 4-12 last season, would join the 2016 Cowboys as the only teams to win 10 of their first 11 games in a season after winning four or fewer games the previous year in NFL history. Below is all the info you need to watch 49ers vs. Packers on Sunday night, including the TV channels and kickoff time.Who plays on Sunday Night Football tonight?Matchup: Green Bay Packers at San Francisco 49ersKickoff time: 8:20 p.m. ETIn our Week 12 NFL picks against the spread and straight-up predictions, Sporting News is split on Sunday night’s game. Below are the explanations for each pick.Pick against the spread: The Packers will have Aaron Rodgers and Aaron Jones coming off a bye to attack a 49ers defense that has shown more vulnerability against offenses with athletic quarterbacks and quick backs. But Green Bay hasn’t played the run well all season, and the diversity and versatility of San Francisco playing off that strength will be difficult to defend. The 49ers have more viable weapons among their backs, wideouts and tight ends for Jimmy Garoppolo than Matt LaFleur can effectively deploy for Rodgers on the road. In this big game under the spotlight, the Niners will barely have the Packers’ number. Pick: 49ers win 30-27 and cover the spread.Straight-up prediction: This is a big one for the NFC playoff picture. Should the 49ers lose to the Packers and give up the inside track to the No. 1 seed, they would be in trouble given their tough schedule over the next few weeks. San Francisco, which up to this point has taken advantage of a relatively light schedule, looks better than Green Bay statistically, but Aaron Rodgers and Co. are coming off a bye completely healthy. The 49ers’ pass rush will make it challenging, but Rodgers will outplay Jimmy Garoppolo on the national stage. Pick: Packers 24, 49ers 20.MORE: NFL TV coverage map for Week 12What channel is Sunday Night Football on?TV channel (national): NBCTV channel (San Francisco): KNTVTV channel (Green Bay): WGBALive stream: NBC Sports App, NBCSports.comAs is the case for all “Sunday Night Football” games on NBC this season, Al Michaels will call the 49ers vs. Packers play-by-play action, and Cris Collinsworth will provide analysis. Michele Tafoya will report from the sidelines, and NFL rules analyst Terry McAulay will explain penalties and other officiating rulings throughout the game. Tonight’s “Sunday Night Football” game is about as big as they come in terms of regular-season NFL matchups. The 49ers, hosting the Packers in a game scheduled to kick off at 8:20 p.m. ET on NBC, are three-point home favorites. That means the game that will give one team the inside track to the No. 1 seed in the NFC playoffs is essentially a toss-up.The 49ers, entering Week 12 with the NFC’s best record at 9-1, are facing the 8-2 Packers. According to the NFL, it marks just the fifth time since 2007 that teams with two or fewer losses have played each other this late in a season. The winners of the last two such games — the Broncos in 2015 and the Seahawks in 2013 — went on to win Super Bowls at the end of those seasons. For those who can’t watch 49ers vs. Packers on TV and wish to find the game on the radio, the San Francisco call can be heard on Sirius channel 83 and XM channel 226, and the Green Bay call can be heard on Sirius channel 81 and XM channel 225.MORE: Watch every NFL game and RedZone on DAZN (Canada only)Sunday Night Football TV schedule 2019All “Sunday Night Football” games start at 8:20 p.m. ET.Week 1Sept. 5 (Thur.)Packers at Bears Sept. 8Steelers at PatriotsWeek 2Sept. 15Eagles at FalconsWeek 3Sept. 22Rams at BrownsWeek 4Sept. 29Cowboys at SaintsWeek 5Oct. 6Colts at ChiefsWeek 6Oct. 13Steelers at ChargersWeek 7Oct. 20Eagles at CowboysWeek 8Oct. 27Packers at ChiefsWeek 9Nov. 3Patriots at RavensWeek 10Nov. 10Vikings at CowboysWeek 11Nov. 17Bears at RamsWeek 12Nov. 24Seahawks at EaglesWeek 13Dec. 1Patriots at TexansWeek 14Dec. 8Seahawks at RamsWeek 15Dec. 15Vikings at ChargersWeek 16Dec. 22Chiefs at BearsWeek 17Dec. 29TBD
Advertisement 9mj9bNBA Finals | Brooklyn Vs6Wingsuit rodeo📽Sindre Efot( IG: @_aubreyfisher @imraino ) t3uykWould you ever consider trying this?😱jgcCan your students do this? 🌚25Roller skating! Powered by Firework Just like in the T20 series, West Indies managed to stake their early claim with an emphatic victory. The visitors knitted a perfect chase as India were left chasing answers at the end of the game in Chennai. Centuries from Shimron Hetmyer and Shai Hope helped the WIndies take the lead in the series with two matches to go. Advertisement Kieron Pollard opted for a bold choice by electing to bowl first on a dry sluggish surface at The Chepauk. The West Indies skipper opted to leave out Evin Lewis, Kharry Pierre, and Brandon King. On the other side, Virat Kohli opted to leave out Manish Pandey, Mayank Agarwal, Chahal and Shardul Thakur from the 15-man squad.The visitors took advantage of the two-paced nature of the pitch and dug in early with slower deliveries. The move paid off dividends as Sheldon Cottrell nicked up the wickets of KL Rahul and Virat Kohli inside the first powerplay itself.Advertisement Rohit Sharma stuck in with patience but his 56-ball vigilance knock ended courtesy off Alzarri Joseph. Coming in at No.5 at a precarious situation Rishabh Pant played with composure en route his maiden ODI fifty.Shreyas Iyer too got to his fifty at the other end as the pair began to lay the foundation for a flourish at the end. The 114-run stand ended with the wicket of Iyer who fell for 70 while Pant followed suit soon after scoring 71 off 69 deliveries.Advertisement Kedar Jadhav and Ravindra Jadeja spiked the run rate with a fifty run stand. The Chennai Super Kings’ duo had their partnership broken with the dismissal of Jadhav. Soon after a bout of controversy plagued with the wicket of the all-rounder.A direct hit from Roston Chase had caught Jadeja short off the crease, but the on-field umpire Shaun George opted to not refer the call upstairs. With the proceedings for the next ball being in process, there was a late appeal by the visitors led by Kieron Pollard who forced the umpire to go upstairs after seeing the replay on the screen. India ended up with 288-8 after the end after a flat finish.Despite notching up the wicket of Sunil Ambris early on, a mammoth second-wicket stand between Shimron Hetmyer and Shai Hope took the game away from the Men In Blue and secured the lead in the process as well.The two teams now head to the coastal city of Vishakapatnam for the second ODI.Read Also:Former India pacer Praveen Kumar allegedly breaks neighbour’s hand and attacks his 7-year old son in drunk stateSachin Tendulkar seeks out hotel staffer who helped him make a key change in his batting technique Advertisement
It’s been more than a decade since Castlegar hockey fans celebrated a Kootenay International Junior Hockey League title.So waiting a few more days shouldn’t be that big of a problem.The North Okanagan Knights staved off elimination by edging out the Rebels 3-2 in Game four of the KIJHL Championship Saturday in Armstrong.Despite being outshot 58-20, the Knights found just enough offence to steal the victory and force Game five of the best-of-seven series Monday back in the Sunflower City. Castlegar holds a commanding 3-1 lead in the series.Dryden Profeit, Connor Richards and Mat Lambert, with the winner in the third, scored for the Knights.That would be all the scoring netminder Dustin Nikkel would need as the game’s first star frustrated the Rebel shooters all game long.Darren Medeiros, unassisted in the second, and Stuart Walton, with time running out in the third, replied for Castlegar.North Okanagan held period leads of 1-0 and 2-1.Castlegar netminder Jordan Gluck lost for the first time in the Championship series.PLAYOFF BANTER: Monday’s puck drop at the Castlegar Complex for Game five is 7:30 p.m. . . .The Victoria Cougars booked tickets to the Cyclone Taylor Cup by sweeping the Comox Valley Glacier Kings in the Vancouver Island Junior Hockey League Final. Victoria joins host Comox Valley in the Cyclone Taylor Cup beginning April 11 on Vancouver Island. . . . Richmond Sockeyes swept out the Aldergrove Kodiaks to win the Pacific Coast Junior Hockey League title and earn a berth into the Cyclone Taylor Cup.
Women 18-29 Category Place Total Number Category Competitor Name 1 1:25:23 1082 Women 18-29 Amanda ROBB 2 1:26:16 1204 Women 18-29 Rebecca LONG 3 1:27:00 1094 Women 18-29 Samantta VILLANUEVA 4 1:28:46 1101 Women 18-29 Jennifer CHUNG 5 1:33:18 1213 Women 18-29 Laura HOWLETT 6 1:34:51 1057 Women 18-29 Keri LEWIS 7 1:36:26 1052 Women 18-29 Diane JMAEFF 8 1:42:03 1054 Women 18-29 Meagan ZUNTI-READ 9 1:42:32 1135 Women 18-29 Kristen SPEARMAN 10 1:42:50 1058 Women 18-29 Samantha HANLEY 11 1:43:57 1099 Women 18-29 Sarah NEUFELD 12 1:45:15 1072 Women 18-29 Shannon HARTSON 13 2:03:16 1165 Women 18-29 Danica LEE Women 30-39 Category Place Total Number Category Competitor Name 1 1:19:27 1111 Women 30-39 Sarah BERRETT 2 1:26:47 1105 Women 30-39 Erica KOCH 3 1:29:40 1215 Women 30-39 Jill AUBIE-VINES 4 1:30:36 1162 Women 30-39 Kristy SHIELDS 5 1:31:02 1088 Women 30-39 Kata POLANO 6 1:32:12 1198 Women 30-39 Vero LALUMIERE 7 1:46:11 1100 Women 30-39 Raegan ETUE 8 1:46:19 1071 Women 30-39 Marissa CARRASCO 9 1:55:40 1168 Women 30-39 Melanie FLYNN 10 1:57:29 1091 Women 30-39 Natasha STEVENSON 11 1:58:29 1130 Women 30-39 Kelley RELKOFF 12 2:08:25 1084 Women 30-39 Lyudmyla VORONINA 13 2:18:54 1137 Women 30-39 Kelsey HARPER Women 40-49 Category Place Total Number Category Competitor Name 1 1:27:17 1180 Women 40-49 Cherie COOPER 2 1:27:29 1216 Women 40-49 Lynda DECHIEF 3 1:29:26 1132 Women 40-49 Daiva VILLA 4 1:31:54 1085 Women 40-49 Sarah GOWER 5 1:33:03 1209 Women 40-49 Alison BROWN 6 1:36:54 1214 Women 40-49 Angie MCTAGUE 7 1:41:59 1117 Women 40-49 Allison BUTLER 8 1:43:18 1107 Women 40-49 Yvonne WERKMANN 9 1:43:38 1064 Women 40-49 Heather FISCHER 10 1:45:26 1068 Women 40-49 Christine MACLEAN 11 1:57:19 1055 Women 40-49 H. CHOPKO BUTLER 12 2:08:22 1073 Women 40-49 Yvonne PHILLIPS 13 2:10:11 1060 Women 40-49 Lisa RAPLEY 14 2:10:11 1063 Women 40-49 Sylvia MARION Women 50-59 Category Place Total Number Category Competitor Name 1 1:22:26 1129 Women 50-59 Danita SCHREIBER 2 1:22:28 1056 Women 50-59 Kim JOLLYMORE 3 1:25:23 1217 Women 50-59 Louise POOLE 4 1:29:11 1164 Women 50-59 Shelly HUME 5 1:33:19 1115 Women 50-59 Dale FROMBERG 6 1:37:40 1095 Women 50-59 Miriam SKELTON 7 1:40:33 1086 Women 50-59 Linda TYNAN 8 1:41:10 1109 Women 50-59 Cheryl MUELLER 9 1:44:56 1133 Women 50-59 Cyndi LYLE 10 1:46:09 1078 Women 50-59 Sylvie MASSE 11 1:55:09 1206 Women 50-59 Marlene TOBIN 12 2:05:03 1124 Women 50-59 Laurilee COMMANDEUR 13 2:09:11 1061 Women 50-59 Judy MOORE 14 3:00:12 1221 Women 50-59 Val YOWEK Women 60+ Category Place Total Number Category Competitor Name 1 1:34:40 1104 Women 60+ Janess IVERSON 2 1:36:16 1076 Women 60+ Judy LLOYD 3 1:53:39 229 Women 60+ Dehbora BIRD 4 1:56:35 1131 Women 60+ Nancy LEWIS 5 1:57:51 1066 Women 60+ Donna SIDDALL 6 2:21:46 1203 Women 60+ Patricia DAVIDOFF Men 16-17 Category Place Total Number Category Competitor Name 1 1:09:45 1140 Men 16-17 Jackson KONKIN Men 18-29 Category Place Total Number Category Competitor Name 1 1:24:00 1211 Men 18-29 James BARKER 2 1:26:13 1121 Men 18-29 Otis LIPPITT 3 1:31:09 1197 Men 18-29 Jarrad MONGER 4 DNF 1053 Men 18-29 Jason GRAY Men 30-39 Category Place Total Number Category Competitor Name 1 1:09:40 1110 Men 30-39 Rob ROTH 2 1:10:00 1141 Men 30-39 Kyle JENSEN 3 1:16:13 1196 Men 30-39 Mike ORSINI 4 1:24:11 1069 Men 30-39 Haru WATANABE 5 1:25:44 1098 Men 30-39 Daniel NEUFELD 6 1:26:30 1102 Men 30-39 Rob PORTERFIELD 7 1:27:31 1092 Men 30-39 Rob MCKENZIE 8 1:59:10 1096 Men 30-39 Andrew LANDRY 9 2:04:26 1136 Men 30-39 Chris THOMPSON Men 40-49 Category Place Total Number Category Competitor Name 1 1:12:32 1093 Men 40-49 Charlie COOPER 2 1:22:02 1202 Men 40-49 Hoher MICHAEL 3 1:23:19 1097 Men 40-49 Scott CARR 4 1:23:49 1116 Men 40-49 Lucas MILLER 5 1:24:06 1134 Men 40-49 Geoffrey INNIS 6 1:25:33 1128 Men 40-49 Iain PARDOE 7 1:29:04 1112 Men 40-49 Tony BEUTEL 8 1:36:32 1207 Men 40-49 Pierre MAGNAN Men 50-59 Category Place Total Number Category Competitor Name 1 1:18:36 1119 Men 50-59 Curtis SCHREIBER 2 1:20:56 1103 Men 50-59 Timothy OLSON 3 1:22:44 1200 Men 50-59 Tom MURRAY 4 1:22:52 1120 Men 50-59 Glenn JOHNSON 5 1:27:01 1081 Men 50-59 Shane PEARSALL 6 1:28:49 1106 Men 50-59 Brent RUNNETT 7 1:30:37 1080 Men 50-59 Hendrik LE ROUX 8 1:31:04 1114 Men 50-59 Mark SCHMUTZ 9 1:31:41 1051 Men 50-59 Paul MCCREEDY 10 1:39:01 1220 Men 50-59 Gary THOMPSON 11 1:42:13 1123 Men 50-59 Victor COMMANDEUR 12 1:58:39 1059 Men 50-59 Bill WAY Men 60+ Category Place Total Number Category Competitor Name 1 1:18:32 1118 Men 60+ Randy TRERISE 2 1:20:05 1218 Men 60+ Andrew KYLE 3 1:24:26 1166 Men 60+ Robert SIMMERLING 4 1:25:13 1077 Men 60+ David LLOYD 5 1:29:51 1070 Men 60+ Peter POLLHAMMER 6 1:42:41 1122 Men 60+ Al SMITH 7 1:49:04 1108 Men 60+ Doug MATTHEWS 8 1:53:20 1067 Men 60+ Robert SIDDALL 9 1:55:07 1087 Men 60+ Peter MOLL 10 2:21:15 1208 Men 60+ Jack WESSEL 33rd Annual Nelson Cyswog ‘N’ Fun Nelson, BC August 2, 2015 Timing by “Results Canada” Sprint Distance Age Group Results Women 16-17 Category Place Total Number Category Competitor Name 1 1:15:51 1139 Women 16-17 Sierra COOPER 2 1:28:26 1142 Women 16-17 Saidy COYNE 3 2:01:06 1138 Women 16-17 Hannah JORDAHL
Ex-Arsenal striker Smith: Cahill not the signing Emery needsby Paul Vegas10 months agoSend to a friendShare the loveFormer Arsenal striker Alan Smith says they should ignore the chance of signing Chelsea captain Gary Cahill.Cahill was heavily linked with the Gunners before he signed for Chelsea from Bolton in January 2012.“Arsenal should have signed Gary Cahill before he went to Chelsea,” Smith told the Daily Express.“He spoke and had a meeting with Arsene Wenger and it didn’t happen.“But he went on to become a fine, fine defender.“Now you’d be signing somebody who’s in his latter years and is not at his peak.“I don’t see that as a goer.” TagsTransfersAbout the authorPaul VegasShare the loveHave your say
Login/Register With: Facebook Advertisement Advertisement LEAVE A REPLY Cancel replyLog in to leave a comment Advertisement I never thought I’d say this, but CBC-TV is on a roll. It began in 2015, with the debut of Schitt’s Creek, a quietly amusing sitcom by Canadian Jewish father-son duo Eugene and Dan Levy. In 2016, CBC introduced Kim’s Convenience, a fluffy story of Korean shopkeepers that has proven to be, if not gut-busting comedy, at least a cute, polished family comedy pushing minority representation across the country.Then came 2017, when Workin’ Moms walked in the door, and elevated CBC-TV to a whole other level.Unlike its saturated siblings, Workin’ Moms adopts a sharper tone, mixing adult themes with blunt swears. Showrunner and star Catherine Reitman has created a firmly 21st-century feminist series on par with other great contemporary, women-led televised series, down to the main character baring her breasts in the pilot episode. (My wife pointed out this bizarre trend to me: the leads of Girls, Orange is the New Black, GLOW and The Marvelous Mrs. Maisel all appear shirtless, not throughout the series, but pointedly in the pilot, as if complying with some unspoken rite of passage.) WORKIN’ MOMS Twitter
The Canadian PressNew federal money for First Nations housing is welcome but will not solve a monumental shortage for at least a generation says Assembly of First Nations Regional Chief Kevin Hart.“I don’t see it happening in my lifetime or in my children’s lifetime, to be honest,” Hart said during a break in the AFN’s housing and infrastructure conference held in Winnipeg.“We have 16, 18 people in a two-bedroom house (in Norway House, Man.). Now if that was to occur here in Winnipeg with a non-native family, would that be acceptable? The black mould that’s in our houses _ would that be acceptable here in Winnipeg? Would that be acceptable in Toronto?”The federal government has promised $8.4 billion over five years for infrastructure, education and other issues in First Nations communities. The housing portion over the next two years is forecast to be more than double previous levels at $450 million.The money is a fraction of what reports have indicated is needed. Internal government documents dated January 2015 and obtained by The Canadian Press early this year pegged the cost of fixing First Nations housing in Manitoba alone at $2 billion.Indigenous Affairs Minister Carolyn Bennett said the government realizes it has a long way to go.“We know that we’ve only begun, and what we’re hearing from coast to coast to coast is people are very happy with the beginning … but no, there is real need out there and we’re going to get going,” she said.In a 20-minute speech at the conference, Bennett said the government is developing ways to ensure funding flows faster to communities in need, and is looking for ways to ensure better, longer-lasting building materials can be used.Hart said cash for housing is needed quickly. He pointed to several communities that have seen a spike in suicides in recent years. Pimicikamak Cree Nation, known as Cross Lake, in northern Manitoba declared a state of emergency last March after six suicides in the community of 8,300.Overcrowded housing, often combined with inadequate recreational facilities and schools, is tied to the despair felt by many residents, he said.“It all relates and it interconnects with proper housing and infrastructure in our communities.”[email protected]
NEW YORK — In the calm before the Christmas storm at the box office, “Ralph Breaks the Internet” remained No. 1 for the third straight week, while the upcoming DC Comics superhero film “Aquaman” arrived with a cannonball-sized splash in Chinese theatres.For the second week in a row, no new wide releases opened in North American theatres, allowing Disney’s animated sequel to again lead domestic ticket sales with $16.1 million, according to studio estimates Sunday.The top six films at the box office were all unchanged. Universal’s “The Grinch,” still a major draw in its fifth weekend, trailed in second with $15.2 million.But the weekend’s biggest new arrival was in China, where Warner Bros.’ “Aquaman” debuted with $93.6 million in ticket sales. That marked a new opening-weekend record for both Warner Bros. and DC in China. Considering the checkered recent history of DC films (“Justice League,” ”Suicide Squad”), the big launch in China was a promising sign for the spinoff starring Jason Momoa.“Adding to the success of ‘Wonder Woman,’ this is a really solid performance and portends big numbers for North America in two weeks when it opens,” said Paul Dergarabedian, senior media analyst for Comscore.He added: “That gives the film a lot of positive momentum. This is a movie, along with ‘Mary Poppins Returns’ and ‘Bumblebee’ and other movies, that’s going to give December that boost that a ‘Star Wars’ movie would give us.”“Aquaman” will expand to 40 international countries next week and arrive in North American theatres Dec. 21.“Aquaman” wasn’t the only big-budget holiday season release receiving a lift this week. Paramount’s “Transformers” prequel “Bumblebee” played a one-night sneak preview in 326 theatres nationwide ahead of its Dec. 21 release.Paramount declined to share ticket figures but domestic distribution chief Kyle Davies said theatres were mostly sold out. Perhaps more importantly, the film directed by Travis Knight and starring Hailee Steinfeld aided its word of mouth with largely glowing reviews — a rarity for the “Transformers” franchise.Disney’s “Mary Poppins Returns,” due out Dec. 19, also helped its cause with four Golden Globe nominations Thursday, including best picture, comedy or musical, and acting nods for Emily Blunt and Lin-Manuel Miranda.The feel-good interracial road trip period tale “Green Book” fared even better at the Globes (five nominations, including best picture, comedy or musical, and acting nods for Maheshala Ali and Viggo Mortensen) and had good results at the box office to show for it. In its fourth week of release, “Green Book” held with a rare 0 per cent drop, earning $3.9 million in 1,181 theatres. It has grossed $20 million in total.Yorgos Lanthimos’ comic period drama “The Favourite” continued to pick up steam. The acclaimed Fox Searchlight release, starring Olivia Colman, Emma Stone and Rachel Weisz, expanded into 91 theatres over the weekend to gross $1.4 million ($15,000 per theatre).A more traditional royal drama, “Mary Queen of Scots,” also opened strongly in limited release. The Focus Features title, starring Saoirse Ronan as Mary Stuart and Margot Robbie as Elizabeth I, debuted in four theatres with a robust $50,045 per-theatre average. Lis Bunnell, president of distribution for Focus, said the film’s modern spin “made it resonate with audiences in a powerful way paralleling so much of what is still going on today for women.”Also opening in limited release were “Ben Is Back,” the family addiction drama with Julia Roberts and Lucas Hedges (a $20,243 per-theatre average in four theatres), and the caustic pop music critique “Vox Lux,” with Natalie Portman (a $27,000 per-theatre average in six theatres).To commemorate the 25th anniversary of Steven Spielberg’s “Schindler’s List,” Universal re-released the Holocaust epic in 1,029 theatres. But it failed to turn out large crowds, grossing a modest $551,000.Next weekend, the box office is expected to be significantly busier with the release of “Spider-Man: Into the Spider-Verse,” ”Once Upon a Deadpool” and Clint Eastwood’s “The Mule” and “Mortal Engines.”Estimated ticket sales for Friday through Sunday at U.S. and Canadian theatres, according to Comscore. Where available, the latest international numbers for Friday through Sunday are also included.1. “Ralph Breaks the Internet,” $16.1 million.2. “The Grinch,” $15.2 million.3. “Creed II,” $10.3 million.4. “Fantastic Beasts: Crimes of Grindelwald,” $6.8 million.5. “Bohemian Rhapsody,” $6 million.6. “Instant Family,” $5.6 million.7. “Green Book,” $3.9 million.8. “Robin Hood,” $3.6 million.9. “Possession of Hannah Grace,” $3.2 million.10. “Widows,” $3.1 million.___Follow AP Film Writer Jake Coyle on Twitter at: http://twitter.com/jakecoyleAPJake Coyle, The Associated Press